6/1/2023 0 Comments Capto adhereTogether with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for mAbs.įor optimal performance of Capto adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates. Second step in mAb chromatographic processĬapto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. mAb S monomers from the aggregates using three mixed- mode chromatography media, CHT, Capto adhere, and. The strong multimodal ligand gives a different selectivity compared to traditional ion exchange (IEX) resins.
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